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Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $38 | In Stock | |
100 mg | $54 | In Stock | |
200 mg | $87 | In Stock | |
500 mg | $144 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. |
In vitro | In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels. |
In vivo | In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity. |
Alias | TriButyrate, Sodium Phenylbutyrate, Buphenyl |
Molecular Weight | 186.18 |
Formula | C10H11NaO2 |
Cas No. | 1716-12-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 18.6 mg/mL (100 mM) DMSO: 50 mg/mL (268.56 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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